“Shear stress enhances expression of the gene encoding the endothelial nitric oxide synthase
(eNOS) and further stimulates its enzymatic activity, leading to physiologic low concentrations of
nitric oxide (NO) within endothelial cells [44–46]. This continuous generation of NO prevents the
apoptosis of endothelial cells, thereby protecting the endothelial monolayer from injury [47,48].”
Is converted into BEL Assertions:
- biologicalProcess(GO:“response to fluid shear stress”) increases rnaAbundance(HGNC:NOS3)
- biologicalProcess(GO:“response to fluid shear stress”) increases
activity(proteinAbundance(HGNC:NOS3), molecularActivity(cat))
- activity(proteinAbundance(HGNC:NOS3), molecularActivity(cat)) directlyIncreases
abundance(CHEBI:“nitric oxide”)
- abundance(CHEBI:“nitric oxide”) decreases biologicalProcess(GO:“apoptotic process”)
the abbreviated BEL Assertions are:
- bp(GO:“response to fluid shear stress”) -> r(HGNC:NOS3)
- bp(GO:“response to fluid shear stress”) -> act(p(HGNC:NOS3), ma(cat))
- act(p(HGNC:NOS3), ma(cat)) => a(CHEBI:“nitric oxide”)
- a(CHEBI:“nitric oxide”) -| bp(GO:“apoptotic process”)
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